PET imaging of the pre‐synaptic dopamine uptake sites in rapid‐onset dystonia‐parkinsonism (RDP)
Identifieur interne : 004C95 ( Main/Exploration ); précédent : 004C94; suivant : 004C96PET imaging of the pre‐synaptic dopamine uptake sites in rapid‐onset dystonia‐parkinsonism (RDP)
Auteurs : Allison Brashear [États-Unis] ; G. Keith Mulholland [États-Unis] ; Qi-Huang Zheng [États-Unis] ; Martin R. Farlow [États-Unis] ; Eric R. Siemers [États-Unis] ; Gary D. Hutchins [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 1999-01.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
- KwdEn :
- Adult, Aged, Brain Mapping, Carbon Radioisotopes, Cocaine (analogs & derivatives), Cocaine (diagnostic use), Comparative study, Corpus Striatum (physiopathology), Corpus Striatum (radionuclide imaging), Diagnosis, Differential, Distribution, Dopamine, Dopamine (metabolism), Dopamine Uptake Inhibitors (diagnostic use), Dystonia, Dystonia (genetics), Dystonia (physiopathology), Dystonia (radionuclide imaging), Emission tomography, Female, Homovanillic Acid (cerebrospinal fluid), Humans, Male, Middle Aged, PET, Parkinson Disease (genetics), Parkinson Disease (physiopathology), Parkinson Disease (radionuclide imaging), Parkinson Disease, Secondary (genetics), Parkinson Disease, Secondary (physiopathology), Parkinson Disease, Secondary (radionuclide imaging), Parkinson disease, Parkinsonism, Pathogenesis, Pilot Projects, Positron, Presynaptic, RDP, Radionuclide study, Rapid process, Receptors, Dopamine (genetics), Receptors, Dopamine (physiology), Receptors, Presynaptic (genetics), Receptors, Presynaptic (physiology), Tomography, Emission-Computed.
- MESH :
- chemical , analogs & derivatives : Cocaine.
- chemical , cerebrospinal fluid : Homovanillic Acid.
- chemical , diagnostic use : Cocaine, Dopamine Uptake Inhibitors.
- chemical , genetics : Receptors, Dopamine, Receptors, Presynaptic.
- chemical , metabolism : Dopamine.
- chemical , physiology : Receptors, Dopamine, Receptors, Presynaptic.
- chemical : Carbon Radioisotopes.
- genetics : Dystonia, Parkinson Disease, Parkinson Disease, Secondary.
- physiopathology : Corpus Striatum, Dystonia, Parkinson Disease, Parkinson Disease, Secondary.
- radionuclide imaging : Corpus Striatum, Dystonia, Parkinson Disease, Parkinson Disease, Secondary.
- Adult, Aged, Brain Mapping, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Pilot Projects, Tomography, Emission-Computed.
Abstract
BACKGROUND: Rapid‐onset dystonia‐parkinsonism (RDP) is a genetic movement disorder characterized by abrupt onset over hours to days of bradykinesia, postural instability, dysphagia, dysarthria, and severe dystonic spasms with decreased levels of the dopamine metabolite, homovanillic acid (HVA), in cerebrospinal fluid (CSF). METHODS: We imaged the dopamine re‐uptake system with [O‐methyl‐11C]β‐CFT ([11C]β‐CFT) in three severely affected individuals with RDP and four patients with idiopathic Parkinson's disease (IPD). Results were compared with those of age‐matched normal volunteers. RESULTS: Positron emission tomography images from those patients with IPD demonstrated a dramatic reduction in the volume of distribution of [11C]β‐CFT whereas patients with RDP showed slightly elevated values. CONCLUSIONS: The data suggest that patients with RDP do not have a decrease in the number of dopamine re‐uptake sites. Our findings suggest that, unlike the situation in IPD, low CSF HVA concentrations seen in RDP patients are not the result of degeneration of striatal dopamine terminals or loss of dopamine re‐uptake sites.
Url:
DOI: 10.1002/1531-8257(199901)14:1<132::AID-MDS1022>3.0.CO;2-J
Affiliations:
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Le document en format XML
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Keith" last="Mulholland">G. Keith Mulholland</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Imaging Sciences, Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Zheng, Qi Uang" sort="Zheng, Qi Uang" uniqKey="Zheng Q" first="Qi-Huang" last="Zheng">Qi-Huang Zheng</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Imaging Sciences, Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Farlow, Martin R" sort="Farlow, Martin R" uniqKey="Farlow M" first="Martin R." last="Farlow">Martin R. Farlow</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, and the Division of Imaging Sciences, Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Siemers, Eric R" sort="Siemers, Eric R" uniqKey="Siemers E" first="Eric R." last="Siemers">Eric R. Siemers</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, and the Division of Imaging Sciences, Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Hutchins, Gary D" sort="Hutchins, Gary D" uniqKey="Hutchins G" first="Gary D." last="Hutchins">Gary D. Hutchins</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Imaging Sciences, Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="1999-01">1999-01</date><biblScope unit="vol">14</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="132">132</biblScope><biblScope unit="page" to="137">137</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">DCCFF22FD077624EAE39149AED7B25B49BFE59A0</idno><idno type="DOI">10.1002/1531-8257(199901)14:1<132::AID-MDS1022>3.0.CO;2-J</idno><idno type="ArticleID">MDS1022</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Carbon Radioisotopes</term><term>Cocaine (analogs & derivatives)</term><term>Cocaine (diagnostic use)</term><term>Comparative study</term><term>Corpus Striatum (physiopathology)</term><term>Corpus Striatum (radionuclide imaging)</term><term>Diagnosis, Differential</term><term>Distribution</term><term>Dopamine</term><term>Dopamine (metabolism)</term><term>Dopamine Uptake Inhibitors (diagnostic use)</term><term>Dystonia</term><term>Dystonia (genetics)</term><term>Dystonia (physiopathology)</term><term>Dystonia (radionuclide imaging)</term><term>Emission tomography</term><term>Female</term><term>Homovanillic Acid (cerebrospinal fluid)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>PET</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Parkinson Disease, Secondary (genetics)</term><term>Parkinson Disease, Secondary (physiopathology)</term><term>Parkinson Disease, Secondary (radionuclide imaging)</term><term>Parkinson disease</term><term>Parkinsonism</term><term>Pathogenesis</term><term>Pilot Projects</term><term>Positron</term><term>Presynaptic</term><term>RDP</term><term>Radionuclide study</term><term>Rapid process</term><term>Receptors, Dopamine (genetics)</term><term>Receptors, Dopamine (physiology)</term><term>Receptors, Presynaptic (genetics)</term><term>Receptors, Presynaptic (physiology)</term><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Cocaine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Homovanillic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Cocaine</term><term>Dopamine Uptake Inhibitors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, Dopamine</term><term>Receptors, Presynaptic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Receptors, Dopamine</term><term>Receptors, Presynaptic</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Carbon Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dystonia</term><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Corpus Striatum</term><term>Dystonia</term><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Corpus Striatum</term><term>Dystonia</term><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pilot Projects</term><term>Tomography, Emission-Computed</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term><term>Distribution</term><term>Dopamine</term><term>Dystonie</term><term>Etude comparative</term><term>Exploration radioisotopique</term><term>Parkinson maladie</term><term>Parkinsonisme</term><term>Pathogénie</term><term>Positon</term><term>Processus rapide</term><term>Présynaptique</term><term>Tomoscintigraphie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND: Rapid‐onset dystonia‐parkinsonism (RDP) is a genetic movement disorder characterized by abrupt onset over hours to days of bradykinesia, postural instability, dysphagia, dysarthria, and severe dystonic spasms with decreased levels of the dopamine metabolite, homovanillic acid (HVA), in cerebrospinal fluid (CSF). METHODS: We imaged the dopamine re‐uptake system with [O‐methyl‐11C]β‐CFT ([11C]β‐CFT) in three severely affected individuals with RDP and four patients with idiopathic Parkinson's disease (IPD). Results were compared with those of age‐matched normal volunteers. RESULTS: Positron emission tomography images from those patients with IPD demonstrated a dramatic reduction in the volume of distribution of [11C]β‐CFT whereas patients with RDP showed slightly elevated values. CONCLUSIONS: The data suggest that patients with RDP do not have a decrease in the number of dopamine re‐uptake sites. Our findings suggest that, unlike the situation in IPD, low CSF HVA concentrations seen in RDP patients are not the result of degeneration of striatal dopamine terminals or loss of dopamine re‐uptake sites.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Indiana</li></region></list><tree><country name="États-Unis"><region name="Indiana"><name sortKey="Brashear, Allison" sort="Brashear, Allison" uniqKey="Brashear A" first="Allison" last="Brashear">Allison Brashear</name></region><name sortKey="Farlow, Martin R" sort="Farlow, Martin R" uniqKey="Farlow M" first="Martin R." last="Farlow">Martin R. Farlow</name><name sortKey="Hutchins, Gary D" sort="Hutchins, Gary D" uniqKey="Hutchins G" first="Gary D." last="Hutchins">Gary D. Hutchins</name><name sortKey="Mulholland, G Keith" sort="Mulholland, G Keith" uniqKey="Mulholland G" first="G. Keith" last="Mulholland">G. Keith Mulholland</name><name sortKey="Siemers, Eric R" sort="Siemers, Eric R" uniqKey="Siemers E" first="Eric R." last="Siemers">Eric R. Siemers</name><name sortKey="Zheng, Qi Uang" sort="Zheng, Qi Uang" uniqKey="Zheng Q" first="Qi-Huang" last="Zheng">Qi-Huang Zheng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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